Influence of DNA-binding on the photochromic equilibrium of a chromene derivative
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Publication Details
Output type: Journal article
Author list: Paramonov SV, Lokshin V, Ihmels H, Fedorova OA
Publisher: Springer
Publication year: 2011
Journal: Photochemical & Photobiological Sciences (1474-905X)
Volume number: 10
Issue number: 8
Start page: 1279
End page: 1282
Number of pages: 4
ISSN: 1474-905X
eISSN: 1474-9092
Languages: English-Great Britain (EN-GB)
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Open access status: bronze
Full text URL: https://link.springer.com/content/pdf/10.1039/c1pp05094j.pdf
Abstract
The photochromic properties of a chromene derivative, which contains a positively charged substituent, were investigated in the presence of ct DNA. Upon irradiation in the absence of DNA the colored quinoid open form is highly unstable and rapidly reverts back to the initial closed form (bleaching). In the presence of DNA the open form is significantly stabilized, presumably because of the association with the macromolecule. The kinetics of the bleaching reaction of the bound ligand were determined and employed to estimate the binding constant.
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