Nutrients and ageing: what can we learn about ageing interactions from animal biology?
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Publication Details
Output type: Journal article
Author list: Stenvinkel P, Kooman JP, Shiels PG
Publisher: Lippincott, Williams & Wilkins
Publication year: 2016
Journal: Current Opinion in Clinical Nutrition and Metabolic Care (1363-1950)
Volume number: 19
Issue number: 1
Start page: 19
End page: 25
Number of pages: 7
ISSN: 1363-1950
eISSN: 1473-6519
Languages: English-Great Britain (EN-GB)
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Open access status: closed
Abstract
Purpose of reviewMany prevalent clinical conditions, such as chronic kidney disease, diabetes mellitus, chronic obstructive pulmonary, and cardiovascular disease associate with features of premature ageing, such as muscle wasting, hypogonadism, osteoporosis, and arteriosclerosis. Studies on various animal models have shown that caloric restriction prolongs lifespan. Studies of animals with unusual long or short life for their body size may also contribute to better understanding of ageing processes. The aim of the present article is to review what we can learn about nutritional modulations and ageing interactions from animal biology.Recent findingsCaloric restriction is a powerful intervention that increases longevity in animals ranging from short-lived species, such as worms and flies, to primates. As long-term studies on caloric restriction are not feasible to conduct in humans, much interest has focused on the impact of caloric restriction mimetics, such as resveratrol, on ageing processes. Recent data from studies on the long-lived naked mole rat have provided important novel information on metabolic alterations and antioxidative defense mechanisms that characterize longevity.SummaryBetter understanding of the biology of exceptionally long-lived animals will contribute to better understanding of ageing processes and novel interventions to extend lifespan also in humans.
Keywords
biomimicry, caloric restriction, naked mole rat, oxidative stress, premature ageing, resveretarol
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