Clinical characteristics and course of spinal cord involvement in Behçet's disease.
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Output type: Journal article
Author list: Yesilot, Mutlu, Gungor, Baykal, Serdaroglu, Akman-Demir
Publisher: Wiley
Publication year: 2007
Volume number: 14
Issue number: 7
Start page: 729
End page: 37
Number of pages: -691
ISSN: 1351-5101
eISSN: 1468-1331
Languages: English-Great Britain (EN-GB)
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Open access status: closed
Abstract
Parenchymal neurological involvement in Behçet's disease (p-NBD) usually presents with a brainstem syndrome; occasionally spinal cord may also be involved. Files of patients with Behçet's disease and spinal cord involvement were reviewed retrospectively, in comparison with other types of p-NBD. Amongst 216 patients with p-NBD, 24 had spinal cord involvement (11%). Most commonly patients presented with sensory-motor symptoms, sphincter and/or sexual dysfunction evolving over days. Four of 10 patients showed single or multiple cervical and/or dorsal lesions on spinal MRI's and one showed dorsal atrophy. Although the clinical picture was variable, it tended to be severe; seven cases had primary progressive course, 11 cases had a secondary progressive course after initial attack(s), four had attacks with severe residual sequela and two had improvement after attacks. After a median follow-up period of 67 months, eight were independent and 14 were dead or dependent, whereas amongst the remaining patients with p-NBD, 113 patients were independent and 56 patients were dead or dependent (P < 0.05). Our study suggests that spinal cord involvement has even worse prognosis compared with other types of p-NBD. Therefore, recognition of spinal cord involvement in Behçet's patients should prompt early vigorous treatment.
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