Role of FDG PET/CT in staging of recurrent ovarian cancer.

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Output type: Book review

Author list: Son, Khan, Rahaman, Cameron, Prasad-Hayes, Chuang, Machac, Heiba, Kostakoglu

Publisher: Radiological Society of North America

Publication year: 2011

Volume number: 31

Issue number: 2

Start page: 569

End page: 83

Number of pages: -485

ISSN: 0271-5333

eISSN: 1527-1323

Languages: English-Great Britain (EN-GB)

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Open access status: closed

Abstract

Ovarian cancer is the fifth leading cause of cancer death among women in the United States and has a high likelihood of recurrence despite aggressive treatment strategies. Detection and exact localization of recurrent lesions are critical for guiding management and determining the proper therapeutic approach, which may prolong survival. Because of its high sensitivity and specificity compared with those of conventional techniques such as computed tomography (CT) and magnetic resonance (MR) imaging, fluorine 18 fluorodeoxyglucose positron emission tomography (PET) combined with CT is useful for detection of recurrent or residual ovarian cancer and for monitoring response to therapy. However, PET/CT may yield false-negative results in patients with small, necrotic, mucinous, cystic, or low-grade tumors. In addition, in the posttherapy setting, inflammatory and infectious processes may lead to false-positive PET/CT results. Despite these drawbacks, PET/CT is superior to CT and MR imaging for depiction of recurrent disease.

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