The negative predictive value of ultrasound-guided 14-gauge core needle biopsy of breast masses: a validation study of 339 cases.
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Output type: Journal article
Author list: Zhang, Lewis, Nasute, Hayes, Warren, Gordon
Publisher: BioMed Central
Publication year: 2012
Volume number: 12
Issue number: 3
Start page: 488
End page: 96
Number of pages: -391
ISSN: 1740-5025
eISSN: 1470-7330
Languages: English-Great Britain (EN-GB)
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Open access status: bronze
Full text URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485647/pdf/ci120047.pdf
Abstract
PURPOSE\nTo determine the negative predictive value of sonographically guided 14-gauge core needle biopsy of breast masses, with detailed analysis of any false-negative cases.\nMATERIALS AND METHODS\nWe reviewed 669 cases of sonographically guided 14-gauge core needle biopsies that had benign pathologic findings. Given a benign pathology on core biopsy, true-negatives had either benign pathology on surgical excision or at least 2 years of stable imaging and/or clinical follow-up; false-negatives had malignant histology on surgical excision.\nRESULTS\nFollow-up was available for 339 breast lesions; 117 were confirmed to be benign via surgical excision, and 220 were stable after 2 years or more of imaging or clinical follow-up (mean follow-up time 33.1 months, range 24-64 months). The negative predictive value was determined to be 99.4%. There were 2 false-negative cases, giving a false-negative rate of 0.1%. There was no delay in diagnosis in either case because the radiologist noted discordance between imaging and core biopsy pathology, and recommended surgical excision despite the benign core biopsy pathology.\nCONCLUSIONS\nSonographically guided 14-gauge core needle biopsy provides a high negative predictive value in assessing breast lesions. Radiologic/pathologic correlation should be performed to avoid delay in the diagnosis of carcinoma.
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