The combination of high sensitivity troponin T and copeptin facilitates early rule-out of ACS: a prospective observational study

Authors / Editors

Ohlin, Bertil

Research Areas

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Publication Details

Output type: Journal article

Author list: Thelin J, Borna C, Erlinge D, Ohlin B

Publisher: BioMed Central

Publication year: 2013

Journal: BMC Cardiovascular Disorders (1471-2261)

Volume number: 13

Number of pages: 8

ISSN: 1471-2261

eISSN: 1471-2261

Languages: English-Great Britain (EN-GB)

Unpaywall Data

Open access status: gold

Full text URL: https://bmccardiovascdisord.biomedcentral.com/counter/pdf/10.1186/1471-2261-13-42

Abstract

Conclusions: In patients presenting with chest pain admitted for observation, the combination of hsTnT and copeptin analyzed at admission had a significantly higher sensitivity to diagnose ACS than hsTnT alone. We report a sensitivity of 83% and a NPV of 91% for the combination of hsTnT and copeptin and we conclude that biomarkers alone are not sufficient to rule out ACS. However, the combination of hsTnT and copeptin seems to have a significantly higher sensitivity to identify ACS than a repeated hsTnT test, and thus enables an earlier risk stratification of chest pain patients. This can be time-saving and beneficial for the individual patient by contributing to early decisions on treatment, need of further assessment and level of care.

Keywords

Acute coronary syndrome, Copeptin, Emergency department, High sensitivity troponin

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