EFFECT OF CISAPRIDE ON RELAPSE OF REFLUX ESOPHAGITIS, HEALED WITH AN ANTISECRETORY DRUG

Authors/Editors

Ohlin, Bertil

Research Areas

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Publication Details

Output type: Journal article

Author list: TYTGAT GNJ, HANSEN OJA, CARLING L, DEGROOT GH, GELDOF H, GLISE H, EFSKIND P, ELSBORG L, KARVONEN AL, OHLIN B, SOLHAUG OH, VERMEERSCH B

Publisher: Taylor and Francis Group

Publication year: 1992

Journal: Scandinavian Journal of Gastroenterology (0036-5521)

Volume number: 27

Issue number: 3

Start page: 175

End page: 183

Number of pages: 9

ISSN: 0036-5521

eISSN: 1502-7708

Languages: English-Great Britain (EN-GB)

Unpaywall Data

Open access status: closed

Abstract

Maintenance treatment with cisapride was evaluated in 298 patients in whom reflux oesophagitis had been healed with antisecretory drugs. Initially, 34% of the patients had grade-I oesophagitis, 33% had grade II, and 33% had grade III. The patients were treated with 20 mg cisapride twice daily or placebo for 6 months or until endoscopic relapse was shown if this occurred earlier. Survival analysis showed that cisapride significantly prolonged the time to endoscopic relapse in grade-I patients (P = 0.02). The intergroup difference in symptomatic relapse in all patients was also significant (P = 0.010). The effect of cisapride was less clearcut in grade II or III, and/or in patients healed with omeprazole. Factors associated with early relapse were placebo therapy, prior omeprazole therapy, duration of pre-trial symptomatic period, and initial endoscopic severity grade. Adverse experiences were limited; diarrhoea was reported by 9% of the cisapride patients.

Keywords

ACID SUPPRESSION, CISAPRIDE, MAINTENANCE TREATMENT, OMEPRAZOLE, REFLUX ESOPHAGITIS, RELAPSE

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