Modulation of motorcortical excitability by methylphenidate in adult voluntary test persons performing a go/nogo task.
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Output type: Journal article
Author list: Buchmann, Dueck, Gierow, Zamorski, Heinicke, Heinrich, Hoeppner, Klauer, Reis, Haessler
Publisher: Springer Verlag (Germany)
Publication year: 2010
Volume number: 117
Issue number: 2
Start page: 249
End page: 58
Number of pages: -190
ISSN: 0300-9564
eISSN: 1435-1463
Languages: English-Great Britain (EN-GB)
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Open access status: closed
Abstract
This study investigated the interaction between motorcortical excitability (short interval cortical inhibition, intracortical facilitation and long interval cortical inhibition), different requirement conditions [choice reaction test (CRT), attention/go/nogo], and their pharmacological modulation by methylphenidate (MPH) in normal healthy adults (n = 31) using a transcranial magnetic stimulation paradigm. MPH was administered in a dosage of 1 mg/kg body weight, maximum 60 mg. Additionally, serum level and clearance of MPH were controlled. The statistical analysis of variance revealed a significant three-way interaction of 2 (MPH) x 3 (CRT) x 6 (ISI) predicting motor evoked potential amplitudes (P = 0.032, MPH none and full dose, n = 31). In order to compare effects of dosage an additional between-subjects factor (half vs. full MPH dose) was introduced. None of the interactions involving this between-subject factor reached statistical significance. Exploring interactions with MPH only, a 3 (MPH none, half and full dose) x 3 (CRT) x 6 (ISI) analysis of variance revealed significant two-way interactions for MPH x ISI (P = 0.040) and condition x ISI (P < 0.001, n = 18). Effects observed for MPH were strongest on facilitatory processes, weaker for intracortical inhibition. In sum, MPH seems to interact via striato-thalamo-cortical pathways with original motorcortical processes (ISI), to a lesser extent with task-dependent or behavioral parameters (CRT).
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