Cyclic peptide marine metabolites and CuII
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Output type: Journal article
Author list: Comba P., Dovalil N., Gahan L., Hanson G., Westphal M.
Publisher: Royal Society of Chemistry
Publication year: 2014
Journal: Dalton Transactions (1477-9226)
Volume number: 43
Issue number: 5
Start page: 1935
End page: 1956
Number of pages: 22
ISSN: 1477-9226
eISSN: 1477-9234
URL: http://api.elsevier.com/content/abstract/scopus_id:84891348184
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Open access status: closed
Abstract
Cyclic pseudo-peptides derived from marine metabolites of the genus Lissoclinum bistratum and Lissoclinum patella have attracted scientific interest in the last two decades. Their structural properties and solution dynamics have been analyzed in detail, elaborate synthetic procedures for the natural products and synthetic derivatives developed, the biosynthetic pathways studied and it now is possible to produce them biosynthetically. Initially, these macrocyclic ligands were studied due to their medicinal and pharmaceutical potential-some of the isolated cyclic pseudo-peptides show high cytotoxic and antiviral activity. A major focus in the last decade has been on their Cu coordination chemistry, as a number of studies have indicated that dinuclear Cu complexes of cyclic peptides may be involved in the ascidians' metabolism, and this is the focus of the present review. © 2014 The Royal Society of Chemistry.
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