Serum lipopolysaccharide-binding protein as a marker of atherosclerosis

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Publication Details

Output type: Journal article

Author list: Serrano M., Moreno-Navarrete J., Puig J., Moreno M., Guerra E., Ortega F., Xifra G., Ricart W., Fernández-Real J.

Publisher: Elsevier

Publication year: 2013

Journal: Atherosclerosis (0021-9150)

Volume number: 230

Issue number: 2

Start page: 223

End page: 227

Number of pages: 5

ISSN: 0021-9150

URL: http://api.elsevier.com/content/abstract/scopus_id:84884565113

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Open access status: closed

Abstract

Background: Recently, serum lipopolysaccharide-binding protein (LBP) has been closely associated with coronary artery disease. Here, we aimed to investigate the possible relationship between serum LBP and markers of atherosclerosis. Methods: Serum LBP and carotid intima media thickness (C-IMT) were measured in 332 subjects (101 men and 231 women) who were recruited from an ongoing multicenter project. Results: Serum LBP was significantly associated with obesity [BMI, fat mass and waist circumference (r>0.38, p<0.0001)], HOMA (r=0.36, p<0.0001) and high sensitivity CRP (hsCRP) (r=0.50, p<0.0001). Circulating LBP was also positively associated with C-IMT (r=0.27, p<0.0001). Circulating LBP (β=0.16; p=0.001) contributed independently to C-IMT variance, after controlling for the effects of age, gender, BMI and hsCRP. Of note, circulating LBP was found to be increased in the population with carotid plaque (n=50; 32.7±12.5 vs 28.7±10.7; p=0.021). Conclusion: The consistent association between serum LBP and the carotid intima media thickness, a widely used atherosclerosis marker, reveals serum LBP as a putative factor related to atherosclerosis. © 2013 Elsevier Ireland Ltd.

Keywords

Atherosclerosis, High sensitivity CRP, LBP, Obesity

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