[Irisin: A messenger from the gods?]

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Publication Details

Output type: Journal article

Author list: Moreno, Moreno-Navarrete, Fernández-Real

Publisher: Elsevier

Publication year: 2013

Journal: Clinic and Research in Arteriosclerosis (0214-9168)

Volume number: 26

Issue number: 3

ISSN: 0214-9168

eISSN: 1578-1879

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Open access status: closed

Abstract

Due to the need to understand the basis of the metabolic benefits of exercise, irisin was discovered a few years ago. This cytokine, secreted by skeletal muscle due to exercise, should have positive effects on energetic metabolism. In particular, it could act as a messenger on white adipose tissue, modifying its phenotype into the beige adipocyte, and increasing its thermogenic capacity. Since it was described, there have been numerous studies led to depict its function, with the aim of determining if irisin could become a therapeutic target in the context of diseases associated with a caloric excess, such as obesity and diabetes. In this review, the irisin discovery is summarized, along with its in vitro and in vivo effects described up until now.

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