Learned helplessness: unique features and translational value of a cognitive depression model.
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Publication Details
Output type: Journal article
Author list: Vollmayr, Gass
Publisher: Springer
Publication year: 2013
Journal: Cell and Tissue Research (0302-766X)
Volume number: 354
Issue number: 1
Start page: 171
End page: 8
Number of pages: -162
ISSN: 0302-766X
eISSN: 1432-0878
Languages: English-Great Britain (EN-GB)
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Open access status: closed
Abstract
The concept of learned helplessness defines an escape or avoidance deficit after uncontrollable stress and is regarded as a depression-like coping deficit in aversive but avoidable situations. Based on a psychological construct, it ideally complements other stress-induced or genetic animal models for major depression. Because of excellent face, construct, and predictive validity, it has contributed to the elaboration of several pathophysiological concepts and has brought forward new treatment targets. Whereas learned helplessness can be modeled not only in a broad variety of mammals, but also in fish and Drosophila, we will focus here on the use of this model in rats and mice, which are today the most common species for preclinical in vivo research in psychiatry.
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