Comparison of gastric histology among Swedish and Japanese patients with peptic ulcer and Helicobacter pylori infection

Authors / Editors

Ohlin, Bertil

Research Areas

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Publication Details

Output type: Journal article

Author list: Kimura K, Sipponen P, Unge P, Ekstrom P, Satoh K, Hellblom M, Ohlin B, Stubberod A, Kihira K, Yube T, Yoshida Y

Publisher: Taylor and Francis Group

Publication year: 2003

Journal: Scandinavian Journal of Gastroenterology (0036-5521)

Volume number: 38

Issue number: 5

Start page: 491

End page: 497

Number of pages: 7

ISSN: 0036-5521

eISSN: 1502-7708

Languages: English-Great Britain (EN-GB)

Unpaywall Data

Open access status: closed

Abstract

Background: The natural course of Helicobacter pylori gastritis may vary between different ethnic groups. Gastric histopathology and the occurrence of H. pylori organisms in the stomach were investigated in healed duodenal (DU) and gastric (GU) ulcer patients recruited in Sweden (S) and Japan (J) in an identical trial. Methods: In 203 patients (JGU = 39, JDU = 55, SDU = 109), various morphological gastritis variables and H. pylori were assessed from biopsy specimens obtained using a specific sampling protocol and interpreted according to guidelines of the updated Sydney grading system. Results: The ratio of GU: DU was observed to be very different between the recruited Japanese (39: 55) and Swedish (0: 109) patients. A comparison of data from SDU and JDU showed that the prevalence of H. pylori infection and the antral predominant gastritis demonstrated by both SDU and JDU were essentially identical. A comparison of data from JDU and JGU demonstrated a greater prevalence of H. pylori infection in the antrum, but not corpus, of JDU compared to JGU patients. The prevalence of atrophy and intestinal metaplasia was higher in both the antrum and corpus of JGU compared to JDU in all patients. Conclusions: The site specified biopsy methodology and standardized interpretation criteria utilized in this study clearly show that the histotopographic profile of Swedish and Japanese DU patients is essentially the same.

Keywords

duodenal/gastric ulcer, ethnicity, Helicobacter pylori infection, histotopographic profile

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