Outcomes and prognostic factors in gallbladder cancer: A single-centre experience
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Publication Details
Output type: Journal article
Author list: Cziupka K., Partecke L., Mirow L., Heidecke C., Emde C., Hoffmann W., Siewert U., Van Den Berg N., Von Bernstorff W., Stier A.
Publisher: Springer
Publication year: 2012
Journal: Langenbeck's Archives of Surgery (1435-2443)
Volume number: 397
Issue number: 6
Start page: 899
End page: 907
Number of pages: 9
ISSN: 1435-2443
eISSN: 1435-2451
URL: http://api.elsevier.com/content/abstract/scopus_id:84865132953
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Open access status: closed
Abstract
Introduction: Gallbladder cancer is the most common malignant tumour of the biliary system with an extraordinarily poor prognosis. In this study, we retrospectively evaluated forty-two patients with histologically proven gallbladder cancer. Patients and methods: Estimated survival rates were calculated by the Kaplan-Meier method, and differences were assessed using the logrank test. The GKR (combined registry of cancer) and demographic data were used to gain information on community cancer statistics. Results: In this study, patients with metastases showed poorer survival rates. Furthermore, the survival was significantly better in patients with R0 resections, smaller tumour sizes and without lymph node infiltration. T stage, M stage and R stage were independent prognostic parameters. Sex and age had no significant effect on survival. Also, we found that patients with incidental gallbladder cancer and those with cholecystolithiasis showed significantly better survival rates. Demographic analyses of the study group confirmed a high coverage of our institution for incident cases in our catchment area and no significant regional deviations from the expected incidence of gallbladder cancer. Conclusion: Despite differences in the incidence in different geographical areas, gallbladder cancer appears to be fairly normally distributed in Western Pomerania, a predominantly rural area of Northeastern Germany. Coverage of incident cases in our catchment area was high. T stage, M stage and R stage were independent prognostic factors in our study. We conclude that, whenever possible, an R0 resection should be the surgical goal in all patients staged resectable before surgery, but heroic resections in patients with highly advanced cancer disease or severe accompanying non-tumour diseases are not warranted. © 2012 Springer-Verlag.
Keywords
Gallbladder cancer, Independent prognostic factors, Survival rate, Treatment outcome
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