Blood-aggregating hydrogel particles for use as a hemostatic agent

Authors/Editors

Behrens, Aditi

Research Areas

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Publication Details

Output type: Journal article

Author list: Behrens A., Sikorski M., Li T., Wu Z., Griffith B., Kofinas P.

Publisher: Elsevier

Publication year: 2013

Journal: Acta Biomaterialia (1742-7061)

Volume number: 10

Issue number: 2

Number of pages: 8

ISSN: 1742-7061

eISSN: 1878-7568

URL: http://api.elsevier.com/content/abstract/scopus_id:84887325818

Unpaywall Data

Open access status: closed

Abstract

The body is unable to control massive blood loss without treatment. Available hemostatic agents are often expensive, ineffective or raise safety concerns. Synthetic hydrogel particles are an inexpensive and promising alternative. In this study we synthesized and characterized N-(3-aminopropyl)methacrylamide (APM) hydrogel particles and investigated their use as a hemostatic material. The APM hydrogel particles were synthesized via inverse suspension polymerization with a narrow size distribution and rapid swelling behavior. In vitro coagulation studies showed hydrogel particle blood aggregate formation as well as bulk blood coagulation inhibition. In vivo studies using multiple rat injury and ovine liver laceration models demonstrated the particles' ability to aid in rapid hemostasis. Subsequent hematoxylin and eosin and Carstairs' method staining of the ovine liver incision sites showed significant hemostatic plug formation. This study suggests that these cationic hydrogel particles form a physical barrier to blood loss by forming aggregates, while causing a general decrease in coagulation activity in the bulk. The formation of a rapid sealant through aggregation and the promotion of local hemostasis through electrostatic interactions are coupled with a decrease in overall coagulation activity. These interactions require the interplay of a variety of mechanisms stemming from a simple synthetic platform. © 2013 Acta Materialia Inc.

Keywords

Hemostasis, Hemostatic, Hydrogel, Polymer

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