Evaluation of six synthetic surgical meshes implanted subcutaneously in a rat model

Authors / Editors

Bryan, Norman

Research Areas

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Publication Details

Output type: Journal article

Author list: Bryan N., Ashwin H., Chen R., Smart N., Bayon Y., Wohlert S., Hunt J.

Publisher: Wiley

Publication year: 2013

Journal: Journal of Tissue Engineering and Regenerative Medicine (1932-6254)

Volume number: 10

Issue number: 10

Number of pages: 11

ISSN: 1932-6254

eISSN: 1932-7005

URL: http://api.elsevier.com/content/abstract/scopus_id:84885454857

Unpaywall Data

Open access status: gold

Full text URL: https://doi.org/10.1002/term.1807

Abstract

The long-term efficacy and mechanical integrity of implanted materials is largely determined by early host response. Therefore, implanting materials with well-characterized tissue responses provides the greatest chance of 'one-hit' surgical successes, without repeated interventions to replace, repair or remove non-compliant biomaterials. Six synthetic meshes were implanted subcutaneously in a rat model to deduce and quantify modulations in host response, based on material fabrication variables. The materials consisted of knitting variations of polypropylene (PP), polyethyleneterephthalate (PET) and polyglycolic acid (PGA) yarns and were implanted for 2, 5, 7, 14 and 28days before fixation and both semi- and fully quantitative histopathology. In a subcutaneous niche, material weight did not influence foreign body response. PET stimulated earlier inflammation than PP and PGA, which normalized over 28days. Multifilament meshes recruited foreign body giant cells, which were largely absent from monofilaments. Using CD68, PGA was demonstrated to be the greatest leukocyte-activating polymer at a number of the time points analysed. This research therefore highlights that underlying polymer composition may be more over-arching in deciding the inflammatory properties of surgical meshes, based on increased macrophagic responses to PGA vs alternative base polymers of comparable weights and porosities. © 2013 John Wiley & Sons, Ltd.

Keywords

Biomaterial, Host response, Inflammation, Polymer, Soft tissue repair

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