Copackaging of different-sized retroviral genomic RNAs: Little effect on retroviral replication or recombination

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Publication Details

Output type: Journal article

Author list: Jones J., Allan R., Seufzer B., Temin H.

Publisher: American Society for Microbiology

Publication year: 1994

Journal: Journal of Virology (0022-538X)

Volume number: 68

Issue number: 6

Start page: 4097

End page: 4103

Number of pages: 7

ISSN: 0022-538X

eISSN: 1098-5514

URL: http://api.elsevier.com/content/abstract/scopus_id:0028228671

Abstract

We tested the effect of copackaging retroviral vectors of different sizes on retroviral replication and recombination. Our results indicate little or no difference in replication or in the rate or pattern of the strand transfers leading to the formation of recombinant proviruses with size. The size difference of the vectors also allowed us to extend our previous analysis of the linkage of markers in the recombinant proviruses. We conclude that the observed linkage is inconsistent with the strand displacement/assimilation model of retroviral recombination.

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